The mechanical regulation of mRNA homeostasis in heart failure – Fabiana Martino, Ph.D.
Fabiana Martino, Ph.D.
Doctoral thesis
The mechanical regulation of mRNA homeostasis in heart failure
The mechanical regulation of mRNA homeostasis in heart failure
Abstract:
Mezi charakteristické patologické změny doprovázející srdeční choroby patří výrazné přestavby, změny kompozice a mechanických vlastnost mezibuněčné hmoty (ECM), což může vést až k selhání vlastního orgánu. Kardiomyocyty reagují na tento bio-mechanický stres změnami exprese fetálních kontraktilních proteinů, změnami na úrovni transkripce a post-transkripčních procesů, jako je alternativní sestřih (AS …moreAbstract:
Cardiac pathologies are characterized by intense remodeling of the composition and mechanics of the extracellular matrix (ECM), a process eventually leading to organ failure. Cardiomyocytes respond to the biomechanical stress posed by cardiac remodeling by re-expressing fetal contractile proteins, by transcriptional and post-transcriptional processes, like alternative splicing (AS). In this study, …more
Language used: English
Date on which the thesis was submitted / produced: 29. 10. 2020
Identifier:
https://is.muni.cz/th/cv05a/
Thesis defence
- Date of defence: 3. 12. 2020
- Supervisor: Ph.D. Giancarlo Forte
- Reader: doc. Mgr. Štěpánka Vaňáčová, Ph.D., Professor Costanza Emanueli
Citation record
Full text of thesis
Contents of on-line thesis archive
Published in Theses:- světu
Other ways of accessing the text
Institution archiving the thesis and making it accessible: Masarykova univerzita, Lékařská fakultaMasaryk University
Faculty of MedicineDoctoral programme / field:
Biomedical sciences / Biochemistry and Molecular Biology
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