Toxicity assessment of kolaviron, biflavonoid from Garcinia kola

Viktorie Vodičková

Bakalářská práce

Abstract:

Garcinia kola (Clusiaceae) is a fruit tree species indigenous to Western and Central Africa. The tree is frequently called ‘wonder plant’ because all its parts have medicinal properties. Garcinia kola is a plant that has been used in traditional African medicine to treat a variety of infectious disorders. The seed of Garcinia kola are commonly chewed as a snack and at the same time there are used for various medicinal purposes and health benefits and that is why the aim of this study was to determined the cytotoxicity of Garcinia kola seeds. In this work, the inhibitory concentration IC50 of human colorectal carcinoma cell lines Caco-2 and HT-29 was determined by the MTT method in toxicity tests of kolaviron-rich G. kola seed extract. As a result, none of the extracts had an inhibitory IC50 concentration against any cell line less than 200 μg/ml. Garcinia kola seeds do not show cytotoxic activity.

Keywords

African flora, multipurpose tree, bitter kola, Southern Nigeria

Jazyk práce: angličtina

Datum vytvoření / odevzdání či podání práce: 15. 4. 2022

Obhajoba závěrečné práce

• Vedoucí: Ing. Olga Leuner, Ph.D.

Česká zemědělská univerzita v Praze

Fakulta tropického zemědělství

Bakalářský studijní program:
Tropické zemědělství