Predikcia chemosenzitivity/chemorezistence na cielenú protinádorovú terapiu u pacientok s karcinómom prsníka a preukázanou HER2 pozitivitou – MUDr. Peter Grell, Ph.D.
MUDr. Peter Grell, Ph.D.
Doctoral thesis
Predikcia chemosenzitivity/chemorezistence na cielenú protinádorovú terapiu u pacientok s karcinómom prsníka a preukázanou HER2 pozitivitou
Prediction of chemosensitivity/chemoresistance to anticancer targeted therapy in patients with HER2 positive breast cancer
Abstract:
Trastuzumab is a humanized monoclonal antibody directed against the HER2 receptor. Trastuzumab-based therapy proved its efficacy in HER2 positive breast cancer in adjuvant setting and in metastatic breast cancer. Despite trastuzumab efficacy, primary or acquired resistance to trastuzumab develops in a large group of patients. PI3K/Akt signaling pathway play critical role in trastuzumab resistance. …moreAbstract:
Trastuzumab je monoklonálna protilátka proti HER2 receptoru. Liečba trastuzumabom preukázala svoju účinnosť u HER2 pozitívnych karcinómov prsníka v adjuvantnej liečbe i u metastatického karcinómu prsníka. Napriek účinnosti trastuzumabu existuje veľká časť pacientok s primárnou alebo získanou rezistenciou. PI3K/Akt signálna dráha hrá dôležitú úlohu v rezistencii na trastuzumab. Cieľom našej práce bolo …more
Language used: Slovak
Date on which the thesis was submitted / produced: 12. 12. 2012
Identifier:
https://is.muni.cz/th/nwzx4/
Thesis defence
- Date of defence: 14. 12. 2012
- Supervisor: prof. MUDr. Rostislav Vyzula, CSc.
Citation record
ISO 690-compliant citation record:
GRELL, Peter. \textit{Predikcia chemosenzitivity/chemorezistence na cielenú protinádorovú terapiu u pacientok s karcinómom prsníka a preukázanou HER2 pozitivitou}. Online. Doctoral theses, Dissertations. Brno: Masaryk University, Faculty of Medicine. 2012. Available from: https://theses.cz/id/49firz/.
Full text of thesis
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Institution archiving the thesis and making it accessible: Masarykova univerzita, Lékařská fakultaMasaryk University
Faculty of MedicineDoctoral programme / field:
Oncology (4-years) / Oncology