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Bc. Matej Fabišik

Master's thesis

Proteinové interakce podjednotek komplexu SMC5/6

Protein-protein interactions of SMC5-6 complex subunits
Abstract:
The Smc5-Smc6 protein dimer creates with subcomplex Nse1-Nse3-Nse4 the Smc5/6 (Structure Maintenance of Chromosome) complex, which is involved in DNA damage repair and replication forks stabilisation. Protein-protein interactions inside of the subcomplex Nse1-Nse3-Nse4 have been described before, but details about protein-protein interactions between protein Nse3 and Smc6 are not known yet. In this …more
Abstract:
Dimer Smc5-Smc6 spolu se subkomplexem Nse1-Nse3-Nse4 vytvaří Smc 5/6 (Structure Maintenance of Chromosome) komplex, který se podílí na opravě poškozené DNA a na stabilizování replikačních vidliček. Proteinové interakce v rámci Nse1-Nse3-Nse4 byly popsány, avšak detaily o interakci proteinu Nse3 s proteinem Smc6 nejsou známy. V této práci se podařilo vytvořit fragmenty proteinu Smc6 a mutanty proteinu …more
 

Keywords

Smc Smc6 Smc5/6 komplex Nse3 Nse1-Nse3-Nse4
 
Language used: Slovak
Date on which the thesis was submitted / produced: 19. 5. 2014
Identifier: https://is.muni.cz/th/lkffz/

Thesis defence

  • Date of defence: 9. 6. 2014
  • Supervisor: doc. Mgr. Jan Paleček, Dr. rer. nat.

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