The effect of tick salivary proteins on innate immunity cells

Mgr. Jana PÁLENÍKOVÁ

Doctoral thesis

Anotácia:

Saliva of Ixodid ticks contains a whole array of pharmacologically active molecules with vasodilatory, antihemostatic, and immunomodulatory activities. This thesis focuses on two types of salivary proteins, serpins and cystatins, and their role in immunomodulation. These protease inhibitors are known to affect many biological functions. To better understand their role in tick saliva we examined their effect on dendritic cells and their ability to modulate the immune response after pathogen infection. As model pathogens, Borrelia spirochetes and tick-borne encephalitis virus were used.

Abstract:

Saliva of Ixodid ticks contains a whole array of pharmacologically active molecules with vasodilatory, antihemostatic, and immunomodulatory activities. This thesis focuses on two types of salivary proteins, serpins and cystatins, and their role in immunomodulation. These protease inhibitors are known to affect many biological functions. To better understand their role in tick saliva we examined their effect on dendritic cells and their ability to modulate the immune response after pathogen infection. As model pathogens, Borrelia spirochetes and tick-borne encephalitis virus were used.

Kľúčové slová

klíštěcí, sliny, přirozená, imunita, dendritické, buňky, buněčná, signalizace

Jazyk práce: Czech

Datum vytvoření / odevzdání či podání práce: 10. 9. 2016

Obhajoba závěrečné práce

• Obhajoba proběhla 14. 12. 2016
• Vedúci: Ing. Jan Kopecký, Ph.D.

UNIVERSITY OF SOUTH BOHEMIA IN ČESKÉ BUDĚJOVICE

Faculty of Science

Doctoral programme / odbor:
Biology / Infection Biology