Genes of innate immunity and their significance in evolutionary ecology of free living rodents – Mgr. Alena Fornůsková, Ph.D.
Mgr. Alena Fornůsková, Ph.D.
Doctoral thesis
Genes of innate immunity and their significance in evolutionary ecology of free living rodents
Genes of innate immunity and their significance in evolutionary ecology of free living rodents
Abstract:
Včasné rozpoznání patogenů je zásadní pro efektivní imunitní odpověď, zajišťující aktivaci adekvátních obranných mechanismů. U obratlovců je obecně zdokumentováno, že molekuly adaptivní imunity, které se účastní rozpoznání patogenů, jsou často předmětem intenzivních selekčních tlaků. Naopak mnohem méně údajů je známo o selekci působící na receptory vrozené imunity. Cílem této práce je popsat variabilitu …moreAbstract:
neboť rozpoznává virové nukleové kyseliny, které jsou značně podobné hostitelským molekulám, a jakákoliv i drobná změna by mohla vést k autoimunitním poruchám.Abstract:
Appropriate recognition of parasites is crucial for effective immune response, ensuring activation of adequate defence mechanisms. In vertebrates, it has frequently been demonstrated that genes encoding proteins involved in pathogen recognition by an adaptive immune system are often subject to intense selection pressures. On the contrary, much less information has been provided on the evolution of …moreAbstract:
tion could cause autoimmunity.
Language used: English
Date on which the thesis was submitted / produced: 19. 12. 2013
Identifier:
https://is.muni.cz/th/rlgj6/
Thesis defence
- Date of defence: 19. 12. 2013
- Supervisor: doc. Mgr. et Mgr. Josef Bryja, Ph.D.
- Reader: prof. MVDr. et RNDr. Petr Hořín, CSc., prof. Dirk Werling
Citation record
ISO 690-compliant citation record:
FORNŮSKOVÁ, Alena. \textit{Genes of innate immunity and their significance in evolutionary ecology of free living rodents}. Online. Doctoral theses, Dissertations. Brno: Masaryk University, Faculty of Science. 2013. Available from: https://theses.cz/id/66629k/.
Full text of thesis
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Institution archiving the thesis and making it accessible: Masarykova univerzita, Přírodovědecká fakultaMasaryk University
Faculty of ScienceDoctoral programme / field:
Biology (4-years) / Zoology
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