Studium interakcí mezi proteiny a RNA pomocí molekulové dynamiky – Bc. Josef Pasulka, Ph.D.
Bc. Josef Pasulka, Ph.D.
Master's thesis
Studium interakcí mezi proteiny a RNA pomocí molekulové dynamiky
Molecular dynamics study of protein and RNA interactions
Abstract:
Pod pojmem RNA interference (RNAi) rozumime mechanismus genove regulace v pritomnosti dvousroubovicove RNA v bunce. Potlacovani RNAi proteiny p19 a B2 bylo studovano biochemickymi metodami. My chceme tuto problematiku protein-RNA komplexu studovat pomoci molekulove dynamiky a popsat pozorovane interakce.Abstract:
RNA interference (RNAi) is an evolutionary conserved mechanism that regulates gene expression in response to the presence of double-stranded RNA (dsRNA) in the cell. The suppression of the RNAi by protein p19 and B2 was studied with biochemical experiments. We want to study the protein-RNA complexes by the molecular dynamics simulation and describe the observed interactions.
Language used: English
Date on which the thesis was submitted / produced: 23. 5. 2008
Identifier:
https://is.muni.cz/th/d6rk5/
Thesis defence
- Date of defence: 17. 6. 2008
- Supervisor: prof. RNDr. Jaroslav Koča, DrSc.
Citation record
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Institution archiving the thesis and making it accessible: Masarykova univerzita, Přírodovědecká fakultaMasaryk University
Faculty of ScienceMaster programme / field:
Biochemistry / Biomolecular Chemistry