Mgr. Helena Pětrošová, Ph.D.

Doctoral thesis

Comparative and Functional Analysis of Treponema pallidum a Leptospira biflexa genomes; Insights into the Unique Biology of Spirochetes

Comparative and Functional Analysis of Treponema pallidum a Leptospira biflexa genomes; Insights into the Unique Biology of Spirochetes
Abstract:
Treponema pallidum ssp. a Leptospira ssp. jsou bakterie patřící do rodiny spirochét. V obou skupinách lze nalézt významné lidské patogeny (původce syfilis a leptospirózy). Cílem této práce bylo identifikovat rozdíly mezi jednotlivými kmeny T. pallidum, a definovat genetické determinanty přispívající k toleranci k toxickým látkám v rodu Leptospira. Celogenomová sekvence tří kmenů T. pallidum (Mexico …more
Abstract:
Treponema pallidum ssp. and Leptospira ssp. are bacteria belonging to the phylum of Spirochetes, and both genera comprise important human pathogens that can cause the diseases syphilis (Treponema) and leptospirosis (Leptospira). The work described in this thesis aimed to identify differences between individual T. pallidum strains at the nucleotide level and to identify mechanism that may be contributing …more
 
 
Language used: English
Date on which the thesis was submitted / produced: 26. 8. 2014

Thesis defence

  • Date of defence: 19. 9. 2014
  • Supervisor: prof. MUDr. David Šmajs, Ph.D.

Citation record

Full text of thesis

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Institution archiving the thesis and making it accessible: Masarykova univerzita, Lékařská fakulta