Epidemiologie myastenie gravis ve Slovenské republice

MUDr. Ivan Martinka, Ph.D.

Doctoral thesis

Epidemiology of Myasthenia Gravis in the Slovak Republic

Abstract:

Purpose: The objective of the study was to evaluate changes of epidemiological parameters in patients with myasthenia gravis (MG) in Slovakia during the period 1977–2015. Methods: Data from medical records of MG patients registered in Slovakia were analyzed. Epidemiological rates (incidence, prevalence, mortality) were assessed for several periods to identify changes and drifts over the period of study. Results: Out of 2074 patients 891 were males (43.0 %), 1183 females (57.0 %). The thymoma associated MG (TAMG) was diagnosed in 123 patients (5.9 %). The mean age at onset shifted from 35.8 years in 1977–1989 to 60.0 years in 2010-2015. The crude incidence increased from 0.36/100.000 in 1977-1989 to 1.70/100.000 in 2010–2015. The average annual incidence of TAMG was 0.05/100.000. Maximum increase of MG incidence was registered in elderly (≥50 years), particularly in group 70-79 years (0.34/100.000 in 1977-1989→7.10/100.000 in 2010-2015) and 80-89 years (0.00/100.000 in 1977-1989→5.31/100.000 in 2010-2015). The crude MG prevalence on 31th December, 2015 was 24.75/100.000. The average MG mortality was 0.27/100.000. Conclusion: The age at onset and incidence increased significantly over the study period due to marked increase of MG incidence in elderly, particularly over 70 years. Possible reasons for this trend are discussed.

Abstract:

Úvod: Cieľom tejto štúdie bolo posúdiť zmeny epidemiologických parametrov u pacientov s myasténiou gravis (MG) v Slovenskej republike v rokoch 1977-2015. Materiál a metodika: Analyzovali sme údaje zo zdravotnej dokumentácie pacientov s MG registrovaných na Slovensku. Zistili sme epidemiologické parametre (incidencia, prevalencia, mortalita) v jednotlivých periódach štúdie, aby sme identifikovali ich zmeny počas obdobia štúdie. Výsledky: Z 2074 pacientov bolo 892 mužov (43,0 %) a 1193 žien (57,0 %). MG asociovaná s tymómom (MGAT) bola diagnostikovaná u 123 patients (5,9 %). Priemerný vek pri vzniku sa posunul z 35,8 roku v 1977–1989 na 60,0 rokov v 2010-2015. Priemerná ročná incidencia sa zvýšila z 0,36/100 000 v 1977-1989 na 1,74/100 000 v 2010–2015. Priemerná ročná incidencia MGAT bola 0,05/100 000. Najvýraznejší nárast incidencie MG sme zaznamenali u starších (≥50 rokov), hlavne v kategórii 70-79 rokov (0,34/100 000 v 1977-1989→7,10/100 000 v 2010-2015) a 80-89 rokov (0,00/100 000 v 1977-1989→5,31/100 000 v 2010-2015). Celková prevalencia MG k 31. 12. 2015 bola 24,75/100 000. Priemerná mortalita bola 0,27/100 000. Záver: Vek pri vzniku a incidencia MG sa signifikantne počas obdobia štúdie hlavne kvôli výraznému nárastu incidencie MG u starších, najmä nad 70 rokov.

Keywords

myasténia gravis, vek pri vzniku, incidencia, prevalencia, mortalita

Language used: Slovak

Date on which the thesis was submitted / produced: 22. 6. 2018

Thesis defence

• Date of defence: 17. 12. 2018
• Supervisor: prof. MUDr. Josef Bednařík, CSc.
• Reader: prof. MUDr. Egon Kurča, PhD., FESO, MUDr. Radim Mazanec, Ph.D., doc. MUDr. Edvard Ehler, CSc.

Masaryk University

Faculty of Medicine

Doctoral programme / field:
Neurology (4-years) / Neurology