Klinický význam nových metod v echokardiografii

MUDr. Vladimír Kincl, Ph.D.

Doctoral thesis

Clinical importance of new echocardiographic methods

Abstract:

Aim: Using of tissue doppler imaging in heart failure risk stratification Methods: In all, 140 patients with symptomatic heart failure and mean ejection fraction of 24% underwent standard echocardiographic examination, Doppler tissue imaging of tricuspid annular motion when parameters Sa, Ea, Aa, IVA and RV Tei index were evaluated and right heart catheterization. The patients were followed up for cardiac related death and non-fatal cardiac events including the implantation of cardioverter-defibrillator and hospitalization for heart failure decompensation. There was performed subsequent analysis of 108 patients when only parameters RV Tei index , IVA and RV IVRT were analysed, and later was add 51 patients without follow-up, correlation a and comparative analyses were perfomed on group of 191 persons. Results: The most powerful prognostic value have combinations Sa ≤10,8 cm/s, Ea ≤ 8,9 cm/s and Tei index ≥1,20 for risk of cardiac death and Ea ≤ 8,9 cm/s with IVA ≤ 2,52 m/s2 for risk of cardiac events. There is a significant inverse relationship between Sa, Ea and pulmonary artery pressure. Patients with diabetes mellitus have significantly lower Ea. Conclusion: Tissue Doppler echocardiography is fast, cheap and widely available diagnostic method and results of our study are usable in clinical practice for heart failure therapy optimalization.

Keywords

tissue Doppler, heart failure, risk stratification

Language used: Czech

Date on which the thesis was submitted / produced: 7. 5. 2008

Thesis defence

• Date of defence: 7. 5. 2008
• Supervisor: prof. MUDr. Jaroslav Meluzín, CSc.

Masaryk University

Faculty of Medicine

Doctoral programme / field:
General Medicine / Internal Medicine