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Mgr. Matej Hajnal

Bachelor's thesis

Metodika bioinformatické analýzy dat ze sekvenování nové generace typu RNA-seq

Bioinformatic analysis of RNA-Seq next-generation sequencing data
Abstract:
The target of this Bachelor's thesis is bioinformatic analysis of next-generation sequencing data obtained from HEK293 cells. cDNA library sequencing allows to compare RNA-seq profile between conditions and therefore had been chosen to determine role of human ZCCHC9 protein by coding gene down-regulation. For this intention has been created workflow, which was used to analyse data and discover differentially …more
Abstract:
Cieľom tejto bakalárskej práce je bioinformatická analýza dát sekvenácie novej generácie cDNA knižnice buniek HEK293. Sekvenácia cDNA knižnice umožňuje porovnať RNA-seq profil medzi podmienkami a bola preto vybraná pre určenie významu ľudského proteínu ZCCHC9 zníženou expresiou kódujúceho génu. Pre tento zámer bol vytvorený postup práce k analýze dát a odhaleniu rozdielnej expresie génov.
 

Keywords

RNA-seq nová generácia sekvenácie génová expresia ZCCHC9 HEK293
 
Language used: Slovak
Date on which the thesis was submitted / produced: 24. 5. 2013
Identifier: https://is.muni.cz/th/g53yk/

Thesis defence

  • Date of defence: 18. 6. 2013
  • Supervisor: doc. Mgr. Štěpánka Vaňáčová, Ph.D.
  • Reader: doc. RNDr. Radka Svobodová Vařeková, Ph.D.

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Institution archiving the thesis and making it accessible: Masarykova univerzita, Fakulta informatiky
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Masaryk University

Faculty of Informatics

Bachelor programme / field:
Applied Informatics / Bioinformatics

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