Direct N1-monosubstitutions of piperazine and applications of their product in syntheses – Mgr. Dana Herová, Ph.D.
Mgr. Dana Herová, Ph.D.
Doctoral thesis
Direct N1-monosubstitutions of piperazine and applications of their product in syntheses
Direct N1-monosubstitutions of piperazine and applications of their product in syntheses
Abstract:
Byla nalezena nová jednoduchá efektivní metoda pro přímou chemoselektivní syntézu derivátů piperazinu, které jsou substituovany v poloze 1 různými elektronakceptorními skupinami. Tato metoda je založena na generování piperazin-1-ium kationtu in situ a jeho reakci s různými elektrofilními činidly, jako jsou acylchloridy, anhydridy, sulfonylchloridy, karbamoylchloridy, popřípadě nitromočovina nebo na …moreAbstract:
The simplified protocol for the routine direct chemoselective preparation of various piperazines substituted in the 1-position by an electron withdrawing group was found. This protocol is based on the reaction of piperazin-1-ium cation with various electrophilic reagents such as acyl chlorides, anhydrides, sulfonyl chlorides, carbamoyl chlorides, and nitrourea or on the mono aza-Michael addition reactions …moreKeywords
Acido-bazické rovnováhy Aza-Michaelovy adice Iontově vázaný substrát Ionty kovu imobilizované na pryskyřici Katalýza kovem 1-Monosubstituovaný piperazin One-pot reakce Piperazin Piperazin-1-ium Solid phase syntéza Acid-base equilibria Aza-Michael addition Ionically-bound substrate Metal catalysis 1-Monosubstituted piperazine One-pot synthesis Piperazine Resin supported metal ion Solid phase synthesis
Language used: English
Date on which the thesis was submitted / produced: 30. 6. 2015
Identifier:
https://is.muni.cz/th/ho8ey/
Thesis defence
- Date of defence: 9. 10. 2015
- Supervisor: doc. RNDr. Pavel Pazdera, CSc.
- Reader: Ing. Pavel Bobáľ, CSc., prof. RNDr. Jan Hlaváč, CSc.
Citation record
ISO 690-compliant citation record:
HEROVÁ, Dana. \textit{Direct N1-monosubstitutions of piperazine and applications of their product in syntheses}. Online. Doctoral theses, Dissertations. Brno: Masaryk University, Faculty of Science. 2015. Available from: https://theses.cz/id/aj7kyr/.
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Institution archiving the thesis and making it accessible: Masarykova univerzita, Přírodovědecká fakultaMasaryk University
Faculty of ScienceDoctoral programme / field:
Chemistry (4-years) / Organic Chemistry