Elucidation of the retrograde transport of contact-dependent inhibition (CDI) toxins through bacterial SecYEG translocon complex – Alfred EMIRI
Alfred EMIRI
Bachelor's thesis
Elucidation of the retrograde transport of contact-dependent inhibition (CDI) toxins through bacterial SecYEG translocon complex
Identification of the driving force behind retrograde transport of contact-dependent inhibition toxins through bacterial SecYEG translocon complex
Abstract:
This study investigates the retrograde translocation of CdiA toxins through the bacterial SecYEG translocon, focusing on the unfolding of the effector domain, proven to be essential for successful transport through the translocon's narrow channel. Using molecular dynamics simulations, the research highlights the pivotal role of pH in influencing the domain unfolding. Additionally, a novel smFRET-adapted …moreAbstract:
This study investigates the retrograde translocation of CdiA toxins through the bacterial SecYEG translocon, focusing on the unfolding of the effector domain, proven to be essential for successful transport through the translocon's narrow channel. Using molecular dynamics simulations, the research highlights the pivotal role of pH in influencing the domain unfolding. Additionally, a novel smFRET-adapted …more
Language used: English
Date on which the thesis was submitted / produced: 9. 5. 2024
Thesis defence
- Supervisor: Mgr. Tomáš Fessl, Ph.D.
Citation record
ISO 690-compliant citation record:
EMIRI, Alfred. \textit{Elucidation of the retrograde transport of contact-dependent inhibition (CDI) toxins through bacterial SecYEG translocon complex}. Online. Bachelor's thesis. České Budějovice: University of South Bohemia in České Budějovice, Faculty of Science. 2024. Available from: https://theses.cz/id/avdw7l/.
The right form of listing the thesis as a source quoted
EMIRI, Alfred. Elucidation of the retrograde transport of contact-dependent inhibition (CDI) toxins through bacterial SecYEG translocon complex. České Budějovice, 2024. bakalářská práce (Bc.). JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH. Přírodovědecká fakulta
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Institution archiving the thesis and making it accessible: JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH, Přírodovědecká fakultaUNIVERSITY OF SOUTH BOHEMIA IN ČESKÉ BUDĚJOVICE
Faculty of ScienceBachelor programme / field:
Biological Chemistry / Biological Chemistry
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Bulánová, L.
10/5/2024