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Bc. Nikola Křapová

Master's thesis

Interakce kaspáz s OspC proteinem B. burgdorferi s.l.

Caspase interaction with OspC protein B. burgdorferi s.l.
Abstract:
OspC protein je vysoce variabilní lipoprotein vyskytující se na povrchu bakterie Borrelie, původce onemocnění Lymeská borelióza. Hlavní roli hraje ve fázi diseminace bakterie do těla hostitele. Některé OspC typy jsou přímo asociovány s invazivitou. V bioinformatické analýze byly OspC typy rozděleny do skupin na invazivní a neinvazivní a nalezeny rozdíly. Z analýzy vyplynuly dva konzervované motivy …more
Abstract:
OspC (outer surface protein C) is high variable lipoprotein which is located on the surface of bacteria Borrelia, causative agent of Lyme disease. This protein plays major role during dissemination into the host. Some OspC types are associated with invasiveness. In bioinformatics part OspC types were divided into invasive and non-invasive groups and then some differences were discovered. The analysis …more
 

Keywords

Borrelie Vnější povrchový protein C invazivní neinvazivní kaspázy štěpení inhibice Borrelia Outer surface protein C invasive noninvasive caspases cleavage inhibition
 
Language used: Czech
Date on which the thesis was submitted / produced: 10. 5. 2017
Identifier: https://is.muni.cz/th/esy1h/

Thesis defence

  • Date of defence: 8. 6. 2017
  • Supervisor: RNDr. Lubomír Janda, Ph.D.

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Institution archiving the thesis and making it accessible: Masarykova univerzita, Přírodovědecká fakulta
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Masaryk University

Faculty of Science

Master programme / field:
Biochemistry / Analytical Biochemistry

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