Mgr. Ondřej Vymazal, Ph.D.

Doctoral thesis

TLR Ligands and Sepsis Induced Signaling of Human Neutrophils and Their Progenitors

TLR Ligands and Sepsis Induced Signaling of Human Neutrophils and Their Progenitors
Abstract:
Tato disertační práce popisuje úlohu signální dráhy kalcineurin nukleární faktor aktivovaných T buněk (CN-NFAT) v lidských neutrofilech. Výsledky získané s využitím RNAseq, qPCR, ELISA, a testu chemotaxe ukázaly, že CN-NFAT inhibitory negativně ovlivňují produkci chemokinů lidskými neutrofily, narušují jejich odpověď na oportunní fungální patogeny, a ovlivňují schopnost neutrofilů přitahovat další …more
Abstract:
This thesis describes the role of the calcineurin nuclear factor of activated T cells (CN NFAT) signalling pathway in human neutrophils. Results obtained using RNAseq, qPCR, ELISA, and chemotaxis assays showed that CN NFAT inhibitors negatively impact neutrophil chemokine production, impairing their response to opportunistic fungal pathogens and affecting immune cell recruitment. The expression of …more
 

Keywords

Neutrophils NFAT chemokines Candida Aspergillus Cyclosporine A Tacrolimus FK506
 
Language used: English
Date on which the thesis was submitted / produced: 19. 9. 2024
Identifier: https://is.muni.cz/th/da1wj/

Thesis defence

  • Date of defence: 28. 11. 2024
  • Supervisor: Mgr. Jan Frič, Ph.D.
  • Reader: doc. Mgr. Michal Pastorek, PhD., Mgr. Jan Dobeš, Ph.D.

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Institution archiving the thesis and making it accessible: Masarykova univerzita, Lékařská fakulta
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Masaryk University

Faculty of Medicine

Doctoral programme / field:
Biomedical sciences / Biochemistry and Molecular Biology

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