Reakce 4-hydroxypyridin-2-onů s halogenačními činidly a reakce získaných halogenderivátů s nukleofily

Bc. Adéla Karteczková

Master's thesis

Reactions of 4-hydroxypyridin-2-ones with Halogenating Agents and Reactions of the Obtained Halogen Derivatives with Nucleophiles

Abstract:

Kondenzací bis(2,4,6-trichlorfenyl)esterů substituované kyseliny malonové s anily methylketonů přpravenými eliminací kyanovodíku z odpovídajících -aminonitrilů, byly připraveny čtyři deriváty 4-hydroxypyridin-2(1H)-onu. Dva z nich byly reakcí se sulfurylchloridem převedeny na odpovídající 3,5-dichlorpyridin-2,4(1H,3H)-diony. Z jednoho 3,5-dichlorpyridin-2,4(1H,3H)-dionu byl reakcí s azidem sodným připraven 3 azido-5-chlorpyridin-2,4(1H,3H)-dion.

Abstract:

By the condensation of bis(2,4,6-trichlorophenyl)esters of substitued malonic acids with methylketone aniles, which were prepared by elimination of hydrogen cyanide from the correspondning -aminonitriles, four derivates of 4 hydroxypyridine 2(1H)-one were synthetized. Two of them were then converted to corresponding 3,5-dichloropyridine-2,4(1H,3H)-diones by reaction with sulfuryl chloride. One of the 3,5-dichloropyridine-2,4(1H,3H)-diones was transformed to 3 azido 5 chloropyridine-2,4(1H,3H)-dione by reaction with sodium azide.

Keywords

syntéza, 4-hydroxypyridin-2(1H)-on, 3, 5-dichlorpyridin-2, 4(1H, 3H)-dion, 3-azido-5-chlorpyridin-2

Language used: Czech

Date on which the thesis was submitted / produced: 12. 5. 2023

Thesis defence

• Supervisor: doc. Ing. Stanislav Kafka, CSc.

Tomas Bata University in Zlín

Faculty of Technology

Master programme / field:
Chemistry of Food and Bioactive Compounds / -