Antibacterial and antiproliferative effects of plant-derived quinoline alkaloids on gut system: A review of literature

Anna Wildová

Bakalářská práce

Abstract:

The gastrointestinal system can be affected by a large variety of diseases, whereas bacterial diarrhoea and colorectal cancer are one of the most common serious ones. Plant-derived molecules such as quinoline and isoquinoline alkaloids are known to be a rich source of diverse scaffolds that could serve as the basis for antimicrobial and anticancer drug design and development. Although their antibacterial and antiproliferative effects on gut system are well reported in the literature, these data have not been systematically analysed yet. The main aim of thesis was a collection and analysis of the data on in vitro antimicrobial and antiproliferative effects of quinoline and isoquinoline alkaloids on human gut bacteria and cells. Data on the plant sources and biological (antibacterial and antiproliferative) activity of alkaloids on gut were collected from scientific databases and summarized in four review tables. As a result, 406 bioactive alkaloids were identified, which were present in 168 plant species belonging to 29 families. 25 molecules were classified as antibacterial agents, and 87 compounds were significantly cytotoxic. The number of taxa containing quinoline and isoquinolines alkaloids was originated in tropical regions. Among all compounds collected from the literature, avicine, neothalfine, dutadrupine, and 6-methoxydihydrosanguinarine have been found to produce significant antimicrobial and/or antiproliferative effects promising for further research, however, further biological tests will be necessary to confirm their efficacy and safety.

Keywords

quinoline, isoquinoline, alkaloids, botany, intestinal infection, intestinal cancer, antibacterial, anticancer

Jazyk práce: angličtina

Datum vytvoření / odevzdání či podání práce: 14. 4. 2022

Obhajoba závěrečné práce

• Vedoucí: prof. Ing. Ladislav Kokoška, Ph.D.

Česká zemědělská univerzita v Praze

Fakulta tropického zemědělství

Bakalářský studijní program:
Tropické zemědělství