Benjamin SCHATZMANN
Bachelor's thesis
Immunometabolic Tumor Therapy
Abstract:
MBTA is a cancer immunotherapy consisting of mannan-BAM, Toll-like receptor agonists, and anti-CD40 antibodies developed by Dr. Ženka. This thesis investigates options for MBTA therapy in combination with the glutamine metabolism inhibitor 6-diazo-5-oxo-L-norleucine (DON). Tolerable DON dosage, different administration modalities, and side effects on mice were investigated. Finally, a potential novel …moreAbstract:
MBTA is a cancer immunotherapy consisting of mannan-BAM, Toll-like receptor agonists, and anti-CD40 antibodies developed by Dr. Ženka. This thesis investigates options for MBTA therapy in combination with the glutamine metabolism inhibitor 6-diazo-5-oxo-L-norleucine (DON). Tolerable DON dosage, different administration modalities, and side effects on mice were investigated. Finally, a potential novel …more
Language used: English
Date on which the thesis was submitted / produced: 9. 5. 2024
Thesis defence
- Supervisor: Mgr. Radka Lencová
Citation record
The right form of listing the thesis as a source quoted
SCHATZMANN, Benjamin. Immunometabolic Tumor Therapy . České Budějovice, 2024. bakalářská práce (Bc.). JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH. Přírodovědecká fakulta
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Institution archiving the thesis and making it accessible: JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH, Přírodovědecká fakultaUNIVERSITY OF SOUTH BOHEMIA IN ČESKÉ BUDĚJOVICE
Faculty of ScienceBachelor programme / field:
Biological Chemistry / Biological Chemistry
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