Crystallization and modelling studies of human oxydosqualene cyclase hOSC wild type and 580W mutant variant – Isabella GUGER
Isabella GUGER
Bachelor's thesis
Crystallization and modelling studies of human oxydosqualene cyclase hOSC wild type and 580W mutant variant
Abstract:
The aim of this study was to learn the basic and advanced crystallization techniques on the model protein Lysozyme, to crystalize the monotopic integral membrane protein human oxidosqualene cyclase hOSC-WT and its mutant variant hOSC-580W and to optimize the initial crystallization experiments. Moreover, the 3D hOSC protein structure was modelled and compared with already known structure of oxidosqualene …moreAbstract:
The aim of this study was to learn the basic and advanced crystallization techniques on the model protein Lysozyme, to crystalize the monotopic integral membrane protein human oxidosqualene cyclase hOSC-WT and its mutant variant hOSC-580W and to optimize the initial crystallization experiments. Moreover, the 3D hOSC protein structure was modelled and compared with already known structure of oxidosqualene …more
Language used: English
Date on which the thesis was submitted / produced: 9. 5. 2019
Thesis defence
- Supervisor: MSc. Tatyana Prudnikova, Ph.D.
Citation record
ISO 690-compliant citation record:
GUGER, Isabella. \textit{Crystallization and modelling studies of human oxydosqualene cyclase hOSC wild type and 580W mutant variant}. Online. Bachelor's thesis. České Budějovice: University of South Bohemia in České Budějovice, Faculty of Science. 2019. Available from: https://theses.cz/id/g720gu/.
The right form of listing the thesis as a source quoted
GUGER, Isabella. Crystallization and modelling studies of human oxydosqualene cyclase hOSC wild type and 580W mutant variant. Č. Budějovice, 2019. bakalářská práce (Bc.). JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH. Přírodovědecká fakulta
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Institution archiving the thesis and making it accessible: JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH, Přírodovědecká fakultaUNIVERSITY OF SOUTH BOHEMIA IN ČESKÉ BUDĚJOVICE
Faculty of ScienceBachelor programme / field:
Biochemistry / Biological Chemistry
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