Studium senzitivity signální dráhy přes receptor Notch na aminokyseliny v potravě

Bc. Pavel STEFFAL

Diplomová práce

Anotace:

The sensitivity of Notch signaling pathway to metabolism has been proposed in several recent studies but it is unclear if the changes in fly diet composition can directly lead to changes in Notch phenotype in vivo. In this work we show that activity of Notch pathway is sensitive to amino acids via the TOR pathway. In addition we will test a candidate protein as a sensor for amino acid level in the fat body of Drosophila melanogaster but also independently in other tissues.

Abstract:

The sensitivity of Notch signaling pathway to metabolism has been proposed in several recent studies but it is unclear if the changes in fly diet composition can directly lead to changes in Notch phenotype in vivo. In this work we show that activity of Notch pathway is sensitive to amino acids via the TOR pathway. In addition we will test a candidate protein as a sensor for amino acid level in the fat body of Drosophila melanogaster but also independently in other tissues.

Klíčová slova

Notch, aminoacids, metabolism, TOR

Jazyk práce: čeština

Datum vytvoření / odevzdání či podání práce: 16. 4. 2018

Obhajoba závěrečné práce

• Vedoucí: RNDr. Alena Bruce, Ph.D.

JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH

Přírodovědecká fakulta

Magisterský studijní program / obor:
Biologie / Experimentální biologie - specializace Buněčná a vývojová biologie