Identification and Characterization of Drug Resistance Mechanisms in cancer cells against Aurora Kinase Inhibitors CYC116 and ZM447439 – Madhusudhan Reddy KOLLAREDDY
Madhusudhan Reddy KOLLAREDDY
Doctoral thesis
Identification and Characterization of Drug Resistance Mechanisms in cancer cells against Aurora Kinase Inhibitors CYC116 and ZM447439
Identification and Characterization of Drug Resistance Mechanisms in cancer cells against Aurora Kinase Inhibitors CYC116 and ZM447439
Abstract:
This PhD thesis is focused on the identification of potential tumor cell resistance mechanisms to a novel Aurora kinase inhibitor CYC116, which has been tested in a Phase I clinical study. Alongside CYC116, we also included an experimental Aurora kinase inhibitor, ZM447439 to generate resistant HCT116 clones.Abstract:
This PhD thesis is focused on the identification of potential tumor cell resistance mechanisms to a novel Aurora kinase inhibitor CYC116, which has been tested in a Phase I clinical study. Alongside CYC116, we also included an experimental Aurora kinase inhibitor, ZM447439 to generate resistant HCT116 clones.
Language used: Czech
Date on which the thesis was submitted / produced: 12. 4. 2013
Accessible from:: 12. 4. 2013
Thesis defence
- Date of defence: 7. 6. 2013
Citation record
ISO 690-compliant citation record:
KOLLAREDDY, Madhusudhan Reddy. \textit{Identification and Characterization of Drug Resistance Mechanisms in cancer cells against Aurora Kinase Inhibitors CYC116 and ZM447439}. Online. Doctoral theses, Dissertations. Olomouc: Palacký University Olomouc, Faculty of Medicine and Dentistry. 2013. Available from: https://theses.cz/id/igq0hk/.
The right form of listing the thesis as a source quoted
KOLLAREDDY, Madhusudhan Reddy. Identification and Characterization of Drug Resistance Mechanisms in cancer cells against Aurora Kinase Inhibitors CYC116 and ZM447439. Olomouc, 2013. disertační práce (Ph.D.). UNIVERZITA PALACKÉHO V OLOMOUCI. Lékařská fakulta
Full text of thesis
Accessibility: Autor si přeje zpřístupnit práci veřejnosti od 12.4.2013
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Published in Theses:- Soubory jsou od 12. 4. 2013 dostupné: světu
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Institution archiving the thesis and making it accessible: UNIVERZITA PALACKÉHO V OLOMOUCI, Lékařská fakultaPALACKÝ UNIVERSITY IN OLOMOUC
Faculty of Medicine and DentistryDoctoral programme / field:
Paediatrics / Pediatrics
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