Comparison of fast single-molecule experiments and simulation of translocation through the SecY translocon.

Volodymyr TSYBULSKYI

Bakalářská práce

Comparison of fast single-molecule experiments and simulations of translocation through the SecY translocon

Abstract:

I have developed a computational package using novel Monte Carlo 1D approach to test current hypotheses of SecYEG translocation against available experimental data. I have also introduced new correlative approach using Protein Structure Networks to process data from molecular dynamics, which will improve success rate in design of future fluorescence experiments in the Laboratory of Single Molecule Fluorescence.

Abstract:

I have developed a computational package using novel Monte Carlo 1D approach to test current hypotheses of SecYEG translocation against available experimental data. I have also introduced new correlative approach using Protein Structure Networks to process data from molecular dynamics, which will improve success rate in design of future fluorescence experiments in the Laboratory of Single Molecule Fluorescence.

Keywords

protein translocation, simulation, SecYEG, 1D Brownian model, molecular motors

Jazyk práce: angličtina

Datum vytvoření / odevzdání či podání práce: 18. 4. 2018

Obhajoba závěrečné práce

• Vedoucí: Mgr. Tomáš Fessl, Ph.D.

JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH

Přírodovědecká fakulta

Bakalářský studijní program / obor:
Applied Informatics / Bioinformatics