Preparation of adjuvant nanoliposomal carriers for construction of recombinant vaccines – Mgr. Eliška Bartheldyová, Ph.D.
Mgr. Eliška Bartheldyová, Ph.D.
Doctoral thesis
Preparation of adjuvant nanoliposomal carriers for construction of recombinant vaccines
Preparation of adjuvant nanoliposomal carriers for construction of recombinant vaccines
Abstract:
Tato disertační práce se zabývá přípravou liposomů pro vakcinaci a targeting. Pro vakcinaci byly použity metalochelatační liposomy s navázaným antigenem, pro targeting na CD44 receptor liposomy s navázanou kyselinou hyaluronovou, pro targeting na dendritické buňky byly použity liposomy s manosylovaným povrchem. Pro navázání proteinu na liposomální nosič byla použita metalochelatační vazba mezi lipidem …moreAbstract:
This Ph. D. Thesis deals with preparation of liposomes for vaccination and targeting. Metallochelatig liposomes with bound antigen were used for vaccination, liposomes with bound hyaluronic acid were used for CD44 targeting and mannosylated liposomes were used for targeting dendritic cells. Metallochelating linkage between DOGS-NTA-Ni lipid and His-tag at the end of the selected protein was used for …more
Language used: English
Date on which the thesis was submitted / produced: 4. 5. 2018
Identifier:
https://is.muni.cz/th/fqlwz/
Thesis defence
- Date of defence: 24. 5. 2018
- Supervisor: doc. RNDr. Jaroslav Turánek, CSc.
- Reader: prof. RNDr. Jan Krejsek, CSc., doc. Mgr. Marek Petřivalský, Ph.D.
Citation record
ISO 690-compliant citation record:
BARTHELDYOVÁ, Eliška. \textit{Preparation of adjuvant nanoliposomal carriers for construction of recombinant vaccines}. Online. Doctoral theses, Dissertations. Brno: Masaryk University, Faculty of Science. 2018. Available from: https://theses.cz/id/ja3wqx/.
Full text of thesis
Contents of on-line thesis archive
Published in Theses:- světu
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Institution archiving the thesis and making it accessible: Masarykova univerzita, Přírodovědecká fakultaMasaryk University
Faculty of ScienceDoctoral programme / field:
Biochemistry (4-years) / Biochemistry
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