Klonování a charakterizace glyceraldehyd-3-fosfát-dehydrogenasy – Bc. Lucia Slepánková
Bc. Lucia Slepánková
Master's thesis
Klonování a charakterizace glyceraldehyd-3-fosfát-dehydrogenasy
Cloning and characterisation of glyceraldehyde-3-phosphate dehydrogenase
Abstract:
Glyceraldehyd-3-fosfátdehydrogenasa je známý enzym, který má svoji nezastupitelnou roli v metabolismu buňky. Tento glykolytický enzym má však mnohé další funkce. Nedávné studie potvrzují, že se GAPDH účastní procesu oprav DNA, apoptotické kaskády nebo je dávána do souvislosti s rakovinou prostaty. Tato práce je zaměřena spíše na její vazebné vlastnosti. GAPDH z bakterie Lactobacillus plantarum má totiž …moreAbstract:
Glyceraldehyde-3-phosphate dehydrogenase enzyme is known for an essential role in cell metabolism. However this glycolytic enzyme but has many other functions. Recent studies confirm that GAPDH participates in the process of DNA repair or apoptosis cascade. It is also probably associated with prostate cancer development. This work is focused more on its binding properties. GAPDH from the bacterium …more
Language used: Czech
Date on which the thesis was submitted / produced: 13. 5. 2011
Identifier:
https://is.muni.cz/th/mdgai/
Thesis defence
- Date of defence: 7. 6. 2011
- Supervisor: prof. RNDr. Michaela Wimmerová, Ph.D.
Citation record
Full text of thesis
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Institution archiving the thesis and making it accessible: Masarykova univerzita, Přírodovědecká fakultaMasaryk University
Faculty of ScienceMaster programme / field:
Biochemistry / Analytical Biochemistry