High resolution sequence-directed mapping of nucleosomes with functional loads – Mgr. Jan Hapala, Ph.D.
Mgr. Jan Hapala, Ph.D.
Doctoral thesis
High resolution sequence-directed mapping of nucleosomes with functional loads
High resolution sequence-directed mapping of nucleosomes with functional loads
Abstract:
V této dizertacní práci zkoumáme rotacní pozice nukleozomu v rídících sekvencích eukaryotických genomu: sestrihová místa, promotory obsahující TATA box a sekvence pripojené k jaderné matrix. Dále sledujeme výskyt nukleozomálního pozicního motivu ve ctyrech eukaryotických genomech. Výsledky našich analýz naznacují dosud neznámé funkce nukleozomu a jejich vliv na evoluci genomu.Abstract:
In this dissertation we have investigated the rotational positioning of nucleosomes in the regulatory sequences of eukaryotic genomes: splice junctions, promoters containing TATA box and nuclear matrix. Further, we have studied occurrence of the nucleosome positioning motif in four eukaryotic genomes. Our results indicate yet unknown functions of nucleosomes and their influence on the evolution of …more
Language used: English
Date on which the thesis was submitted / produced: 17. 10. 2014
Identifier:
https://is.muni.cz/th/zjrbs/
Thesis defence
- Date of defence: 23. 10. 2014
- Supervisor: prof. Ing. Eduard Nikolajevič Trifonov, Ph.D.
- Reader: RNDr. Roman Hobza, PhD., doc. RNDr. Eduard Kejnovský, CSc.
Citation record
ISO 690-compliant citation record:
HAPALA, Jan. \textit{High resolution sequence-directed mapping of nucleosomes with functional loads}. Online. Doctoral theses, Dissertations. Brno: Masaryk University, Faculty of Science. 2014. Available from: https://theses.cz/id/jwsah4/.
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Institution archiving the thesis and making it accessible: Masarykova univerzita, Přírodovědecká fakultaMasaryk University
Faculty of ScienceDoctoral programme / field:
Biochemistry (4-years) / Genomics and Proteomics
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