Mgr. Lenka Mikalová, Ph.D.

Doctoral thesis

Comparative genomics of Treponema pallidum subspecies and molecular diagnostics of syphilis in the Czech Republic

Comparative genomics of Treponema pallidum subspecies and molecular diagnostics of syphilis in the Czech Republic
Abstract:
Rod Treponema zahrnuje několik druhů a poddruhů patogenních spirochet. Mezi klinicky nejvýznamnější lidské patogeny patří Treponema pallidum subsp. pallidum (TPA), původce syfilis; T. pallidum subsp. pertenue (TPE), původce yaws; T. pallidum subsp. endemicum (TEN), původce endemické syfilis. Studium těchto patogenů je limitováno skutečností, že tyto treponemy nelze kultivovat v podmínkách in vitro …more
Abstract:
The genus Treponema comprises several human pathogenic spirochetes including T. pallidum subsp. pallidum (TPA), T. pallidum subsp. pertenue (TPE), T. pallidum subsp. endemicum (TEN), the causative agents of syphilis, yaws and endemic syphilis, respectively. The study of these pathogens is limited by the fact that these treponemes cannot be cultivated under in vitro conditions. Seven treponemal strains …more
 
 
Language used: English
Date on which the thesis was submitted / produced: 26. 9. 2013

Thesis defence

  • Date of defence: 27. 9. 2013
  • Supervisor: prof. MUDr. David Šmajs, Ph.D.

Citation record

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Institution archiving the thesis and making it accessible: Masarykova univerzita, Lékařská fakulta