Small protein with a big function – Mgr. Barbora Štefanovie, Ph.D.
Mgr. Barbora Štefanovie, Ph.D.
Doctoral thesis
Small protein with a big function
Small protein with a big function
Abstract:
Nestabilita genómu zohráva kľúčovú úlohu pri vzniku a vývoji rakoviny. Bezchybná oprava DNA poškodení, ktoré vznikajú počas bunkového metabolizmu alebo pôsobením vonkajších faktorov, je nevyhnutná pre udržanie stability genetického materiálu bunky. Táto práca sa zaoberá štúdiom homologickej rekombinácie (HR) zabezpečujúcej opravu dvojvláknových zlomov, ktoré sú pre bunky zvlášť nebezpečné, pretože …moreAbstract:
Genomic instability plays critical role in cancer initiation and progression. Therefore, the proper repair of DNA lesions arising either during normal cell metabolism or by action of exogenous agents, is crucial to maintain genetic material intact and thus prevent cancer. In this thesis, we focus on the repair of double strand breaks (DSBs) by homologous recombination (HR). DSBs are extremely dangerous …more
Language used: English
Date on which the thesis was submitted / produced: 12. 9. 2018
Identifier:
https://is.muni.cz/th/lnksm/
Thesis defence
- Date of defence: 3. 6. 2019
- Supervisor: doc. Mgr. Lumír Krejčí, Ph.D.
- Reader: prof. Michael Lisby, Konstantinos Tripsianes, Ph.D.
Citation record
Full text of thesis
Contents of on-line thesis archive
Published in Theses:- světu
Other ways of accessing the text
Institution archiving the thesis and making it accessible: Masarykova univerzita, Lékařská fakultaMasaryk University
Faculty of MedicineDoctoral programme / field:
Medical Biology (4-years) / Medical Biology
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