Integration and analysis of the effects of an unnatural amino acid into transmembrane 4 of the Orai1 protein – Bc. et Bc. Helene Sabine GEMEINHARDT
Bc. et Bc. Helene Sabine GEMEINHARDT
Master's thesis
Integration and analysis of the effects of an unnatural amino acid into transmembrane 4 of the Orai1 protein
Intergration and analysis of the effects of an unnatural amino acids into transmembrane 4 or the Orai1 protein
Abstract:
In this work intramolecular interactions of the Orai1 protein are investigated by integrating the unnatural amino acid p-Azido-L-phenylalanine (Azi) at different positions (A254, V252 and G247) of the Orai's transmembrane domain 4 (TM4). The compound Azi is unreactive under physiological conditions but can be activated using UV-light. Being reactive it can form covalent bonds with nearby residues. …moreAbstract:
In this work intramolecular interactions of the Orai1 protein are investigated by integrating the unnatural amino acid p-Azido-L-phenylalanine (Azi) at different positions (A254, V252 and G247) of the Orai's transmembrane domain 4 (TM4). The compound Azi is unreactive under physiological conditions but can be activated using UV-light. Being reactive it can form covalent bonds with nearby residues. …more
Language used: English
Date on which the thesis was submitted / produced: 12. 12. 2023
Thesis defence
- Supervisor: Dr. Isabella Derler
Citation record
ISO 690-compliant citation record:
GEMEINHARDT, Helene Sabine. \textit{Integration and analysis of the effects of an unnatural amino acid into transmembrane 4 of the Orai1 protein}. Online. Master's thesis. České Budějovice: University of South Bohemia in České Budějovice, Faculty of Science. 2023. Available from: https://theses.cz/id/kzv1na/.
The right form of listing the thesis as a source quoted
GEMEINHARDT, Helene Sabine. Integration and analysis of the effects of an unnatural amino acid into transmembrane 4 of the Orai1 protein. České Budějovice, 2023. diplomová práce (Mgr.). JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH. Přírodovědecká fakulta
Full text of thesis
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Published in Theses:- Soubory jsou nedostupné do 12. 12. 2026
- Po tomto datu bude práce dostupná: světu
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Institution archiving the thesis and making it accessible: JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH, Přírodovědecká fakultaUNIVERSITY OF SOUTH BOHEMIA IN ČESKÉ BUDĚJOVICE
Faculty of ScienceMaster programme / field:
Biological Chemistry / Biological Chemistry
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