Preparation and characterization of pluripotent stem cell-derived cardiomyocyte - In vitro model of cardiomyopathy – Bc. Zuzana Tomášiková
Bc. Zuzana Tomášiková
Master's thesis
Preparation and characterization of pluripotent stem cell-derived cardiomyocyte - In vitro model of cardiomyopathy
Preparation and characterization of pluripotent stem cell-derived cardiomyocyte - In vitro model of cardiomyopathy
Abstract:
Kyselina retinová (retinoic acid, RA) je metabolit retinolu, vitamínu A, působící jako morfogen a teratogen. Ukázalo se, že RA má komplexní účinky na vývoj srdce a WNT signální dráhu, ale vztah mezi nimi stále není plně pochopen. Bylo pozorováno, že během in vitro diferenciace myších embryonálních kmenových buněk může přidání RA nebo inhibice WNT indukovat kardiomyogenezi a následnou buněčnou specifikaci …moreAbstract:
Retinoic acid (RA) is a metabolite of retinol, vitamin A, acting as morphogen and tera-togen. RA has been shown to have complex effects on heart development and WNT signalling, but the relationship between the two is still not fully understood. We have observed that during in vitro differentiation of murine embryonic stem cells addition of RA or WNT inhibition can induce cardiomyogenesis and subsequently …more
Language used: English
Date on which the thesis was submitted / produced: 15. 5. 2023
Identifier:
https://is.muni.cz/th/bt6vq/
Thesis defence
- Date of defence: 29. 6. 2023
- Supervisor: Mgr. Jiří Pacherník, Ph.D.
- Reader: Mgr. Olga Vondálová Blanářová, Ph.D.
Citation record
ISO 690-compliant citation record:
TOMÁŠIKOVÁ, Zuzana. \textit{Preparation and characterization of pluripotent stem cell-derived cardiomyocyte - In vitro model of cardiomyopathy}. Online. Master's thesis. Brno: Masaryk University, Faculty of Science. 2023. Available from: https://theses.cz/id/lieu44/.
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Institution archiving the thesis and making it accessible: Masarykova univerzita, Přírodovědecká fakultaMasaryk University
Faculty of ScienceMaster programme / field:
Experimental Animal Biology and Immunology / Developmental Biology
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