Endogenous and xenobiotic indoles as modulators of the AhR and PXR signalling pathways – Mgr. Barbora VYHLÍDALOVÁ
Mgr. Barbora VYHLÍDALOVÁ
Doctoral thesis
Endogenous and xenobiotic indoles as modulators of the AhR and PXR signalling pathways
Endogenous and xenobiotic indoles as modulators of AhR and PXR signaling pathways
Abstract:
The human microbiome produces diverse metabolites that affect human health. A distinct class of microbial catabolites is formed from dietary tryptophan, some of which have already been described as ligands of the aryl hydrocarbon receptor (AhR) and the pregnane X receptor (PXR). Both receptors act as sensors for endogenous and exogenous compounds, and thus regulate gene expression of drug metabolizing …moreAbstract:
Lidský mikrobiom produkuje rozmanité metabolity, které ovlivňují lidské zdraví. Jedna skupina mikrobiálních katabolitů je tvořena z tryptofanu přijatého v potravě, z nichž některé již byly popsány jako ligandy aryl uhlovodíkového receptoru (AhR) a pregnanového X receptoru (PXR). Oba receptory působí jako xenoreceptory endogenních i exogenních sloučenin a regulují tak genovou expresi enzymů metabolizujících …more
Language used: English
Date on which the thesis was submitted / produced: 30. 8. 2022
Thesis defence
- Supervisor: prof. RNDr. Zdeněk Dvořák, DrSc.
Citation record
ISO 690-compliant citation record:
VYHLÍDALOVÁ, Barbora. \textit{Endogenous and xenobiotic indoles as modulators of the AhR and PXR signalling pathways}. Online. Doctoral theses, Dissertations. Olomouc: Palacký University Olomouc, Faculty of Science. 2022. Available from: https://theses.cz/id/n4d927/.
The right form of listing the thesis as a source quoted
VYHLÍDALOVÁ, Barbora. Endogenous and xenobiotic indoles as modulators of the AhR and PXR signalling pathways. Olomouc, 2022. disertační práce (Ph.D.). UNIVERZITA PALACKÉHO V OLOMOUCI. Přírodovědecká fakulta
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Institution archiving the thesis and making it accessible: UNIVERZITA PALACKÉHO V OLOMOUCI, Přírodovědecká fakultaPalacký University Olomouc
Faculty of ScienceDoctoral programme / field:
Biology / Molecular and Cell Biology
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MARKLOVÁ, E.
31/8/2022