Inkorporace hydrofilního/hydrofobního léčiva do biologicky odbouratelných nanovlákenných materiálů jako systémy pro dodávání léčiv

Marta Tomillo Amorós

Master's thesis

Incorporation of hydrophilic/hydrophobic drug into biodegradable nanofibrous materials as drug delivery systems

Abstract:

This thesis investigates the comparative performance of Direct Current Electrospinning (DCES) and Alternating Current Electrospinning (ACES) technologies for the development of nanofibrous membranes used in drug delivery systems (DDS). The study focuses on the incorporation of curcumin, a hydrophobic compound known for its anti-inflammatory and anticancer properties, into Polylactic Acid (PLA) nanofibers. DCES and ACES methods were evaluated in terms of spinnability, fiber morphology, orientation, and thermal properties using Differential Scanning Calorimetry (DSC) and Thermogravimetric Analysis (TGA). The findings demonstrate that both DCES and ACES can produce nanofibers with desirable characteristics, but each method exhibits distinct advantages. Despite the presence of some fiber defects and incomplete curcumin dissolution in both methods, the resulting nanofibrous membranes displayed good potential for use in drug delivery applications. This research contributes to the understanding of ACES technology's applicability in DDS and highlights the importance of optimizing electrospinning parameters for the effective integration of active pharmaceutical ingredients into biodegradable nanofibers.

Abstract:

Tato diplomova prace zkouma porovnani technologii stejnosmerneho elektrickeho zvlaknovani (DCES) a stridaveho elektrickeho zvlaknovani (ACES) pro vyvoj nanovlakennych membran pouzivanych v systemech pro dodavani leciv (DDS). Studie se zameruje na inkorporaci kurkuminu, hydrofobni slouceniny zname pro sve protizanetlive a protinadorove vlastnosti, do nanovlaken z kyseliny polymlecne (PLA). Metody DCES a ACES byly hodnoceny z hlediska zvlaknitelnosti, morfologie vlaken, orientace a tepelnych vlastnosti pomoci diferencialni skenovaci kalorimetrie (DSC) a termogravimetricke analyzy (TGA). Vysledky ukazuji, ze obe metody DCES i ACES jsou schopne produkovat nanovlakna s pozadovanymi vlastnostmi, ale kazda metoda vykazuje odlisne vyhody. Navzdory pritomnosti nekterych defektu vlaken a neuplnemu rozpusteni kurkuminu u obou metod vykazovaly vysledne nanovlakenne membrany dobry potencial pro pouziti v systemech pro dodavani leciv. Tento vyzkum prispiva k pochopeni aplikovatelnosti technologie ACES v DDS a zduraznuje dulezitost optimalizace parametru electrospinningu pro efektivni integraci ucinnych farmaceutickych latek do biologicky odbouratelnych nanovlaken.

Keywords

Nanovlakenne membrany, stejnosmerne elektricke zvlaknovani (DCES), Stridave elektricke zvlaknovani (ACES), Systemy pro dodavani leciv (DDS), Kurkumin, Kyselina polymlecna (PLA), Morfologie vlaken, Tepelne vlastnosti, Diferencialni skenovaci kalorimetrie (DSC), Termogravimetricka analyza (TGA), Hydrofobni leciva, Biologicky odbouratelna nanovlakna.

Language used: English

Date on which the thesis was submitted / produced: 30. 8. 2024

Thesis defence

• Supervisor: doc. Ing. Jiří Chvojka, Ph.D.

Technical University of Liberec

Faculty of Textile Engineering

Master programme / field:
Textile Engineering / Nonwovens and Nanofiber Materials