An analysis of the interactions of adenovirus vectors and human cytomegalovirus with host cells – Mgr. Mariana Pjechová, Ph.D.
Mgr. Mariana Pjechová, Ph.D.
Doctoral thesis
An analysis of the interactions of adenovirus vectors and human cytomegalovirus with host cells
An analysis of the interactions of adenovirus vectors and human cytomegalovirus with host cells
Abstract:
V této práci jsme studovali vliv virových infekcí na buněčné imunitní systémy prostřednictvím analýzy změn signálních drah a změn receptorů na buněčných površích infikovaných buněk. Použili jsme dva různé typy adenovirových vektorů pro genovou terapii, vektor RAd592 AdEasy1 (adenovirus 5 ΔE1/E3) a vektor RAd1640 AdZ2 (adenovirus 5 ΔE1/E3/E4 (se zachovaným E4ORF6)). Následně jsme studovali interakce …moreAbstract:
In this thesis work the impact of virus infections on cell immune systems were studied by analysing for changes in signalling pathways and changes in receptors on the cell surfaces of infected cells. Two different types of adenovirus gene therapy vectors, RAd592 AdEasy1 (adenovirus 5 ΔE1/E3) and RAd1640 AdZ2 (adenovirus 5 Δ E1/E3/E4 (with non-deleted E4ORF6)), were used. Subsequently, we studied cell …more
Language used: English
Date on which the thesis was submitted / produced: 5. 3. 2020
Identifier:
https://is.muni.cz/th/xamum/
Thesis defence
- Date of defence: 11. 9. 2020
- Supervisor: RNDr. Bořivoj Vojtěšek, DrSc.
- Reader: doc. Mgr. Václav Brázda, Ph.D., prof. Ing. Miroslav Strnad, CSc. DSc.
Citation record
ISO 690-compliant citation record:
PJECHOVÁ, Mariana. \textit{An analysis of the interactions of adenovirus vectors and human cytomegalovirus with host cells}. Online. Doctoral theses, Dissertations. Brno: Masaryk University, Faculty of Science. 2020. Available from: https://theses.cz/id/nn3czc/.
Full text of thesis
Contents of on-line thesis archive
Published in Theses:- světu
Other ways of accessing the text
Institution archiving the thesis and making it accessible: Masarykova univerzita, Přírodovědecká fakultaMasaryk University
Faculty of ScienceDoctoral programme / field:
Molecular and Cell Biology and Genetics / Molecular and Cell Biology and Genetics
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