Mgr. Peter Holub, Ph.D.

Doctoral thesis

Functional and structural characterization of key players in RNA quality control: the exosome, TRAMP and NRD1 complexes

Functional and structural characterization of key players in RNA quality control: the exosome, TRAMP and NRD1 complexes
Abstract:
Kontrolou kvality RNA nazýváme soubor procesů odpovědných za udržování homeostáze různých druhů RNA molekul v buňce. V nedávné době byly tyto procesy popsány u organizmů počínaje jednobuňečnými kvasinkami a konče člověkem. V práci nabizím úvod do problematiky kontroly kvality RNA a shrnuji data získané o klíčových hráčích této dráhy v Saccharomyces cerevisiae: exosomu a komplexech TRAMP a NRD1. Představuji …more
Abstract:
The RNA quality control is a set of processes responsible for maintaining the homeostasis of different RNA species in cell. It was recently described in organisms ranging from unicellular yeast to humans. Here I provide an introduction to this topic and sum up the data I have obtained on the key players of RNA quality control in Saccharomyces cerevisiae in the course of my PhD work: the exosome, TRAMP …more
 
 
Language used: English
Date on which the thesis was submitted / produced: 28. 1. 2013

Thesis defence

  • Date of defence: 27. 2. 2013
  • Supervisor: doc. Mgr. Štěpánka Vaňáčová, Ph.D.
  • Reader: Mgr. Dalibor Blažek, Ph.D., doc. Mgr. David Staněk, Ph.D.

Citation record

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Institution archiving the thesis and making it accessible: Masarykova univerzita, Přírodovědecká fakulta