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Mgr. Veronika Ostapčuk

Bachelor's thesis

Kontrola kvality RNA u eukaryot

RNA quality control in the cell nucleus
Abstract:
Poly(A) polymerasy jsou všeobecně známy jako enzymy zodpovědné za polyadenylaci 3´konce prekurzorové mRNA v jádře eukaryot. Vyskytují se však i v bakteriích, v nichž zastávají naprosto odlišnou fuknci. Polyadenylace nevede ke stabilizaci mRNA, jako je tomu v eukaryotech, ale k degradaci. V posledních letech byly v eukaryotech objeveny další poly(A) polymerasy, a to jak v jádře tak v cytoplazmě. Jednou …more
Abstract:
Poly(A) polymerases are well known as enzymes responsible for polyadenylation of 3´ends of precursore mRNA in nucleus of eukaryotes. However there is also poly(A) polymerase in bacteria which mediates completly different function. Polyadenylation does not stabilize the mRNA like in eukaryotes but determines it for degradation. In last few years new poly(A) polymerases were found in cytoplasm and nucleus …more
 

Keywords

PolyA polymerasa Trf4 protein expresní systém Pichia pastoris
 
Language used: Czech
Date on which the thesis was submitted / produced: 14. 5. 2009
Identifier: https://is.muni.cz/th/gbhtw/

Thesis defence

  • Date of defence: 16. 6. 2009
  • Supervisor: doc. Mgr. Štěpánka Vaňáčová, Ph.D.

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Institution archiving the thesis and making it accessible: Masarykova univerzita, Přírodovědecká fakulta
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Masaryk University

Faculty of Science

Bachelor programme / field:
Biochemistry / Biochemistry

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