Bc. Tereza Slamečková

Bachelor's thesis

Analysis of the immune checkpoint inhibitors expression on gamma-delta T lymphocytes in CML patients during therapy

Analysis of the immune checkpoint inhibitors expression on gamma-delta T lymphocytes in CML patients during therapy
Abstract:
Chronická myeloidní leukémie (CML) je časté myeloproliferativní onemocnění, které je charakterizováno reciproční translokací t(9;22), tzv. Philadelphia chromozomem. Gamma-delta T-lymfocyty jsou efektorové lymfocyty přirozené imunity podílející se na protinádorovém dozoru. Inhibitory kontrolních bodů jsou receptory exprimované na efektorových buňkách imunitního systému. Jejich ligandy jsou exprimovány …more
Abstract:
Chronic myeloid leukaemia is a frequent myeloproliferative disease, characterised by reciprocal translocation t(9;22), known as the Philadelphia chromosome. Gamma-delta T cells are effector cells of the innate immune system contributing to immune surveillance. Immune checkpoint inhibitors are receptors expressed on effector immune cells. Their corresponding ligands are expressed on tumour cells and …more
 

Keywords

chronická myeloidní leukémie imunita imunitní kontrolní body gamma-delta T-lymfocyty terapie chronic myeloid leukaemia immunity immune checkpoints gamma-delta T lymphocytes therapy
 
Language used: English
Date on which the thesis was submitted / produced: 2. 5. 2024
Identifier: https://is.muni.cz/th/jxhop/

Thesis defence

  • Date of defence: 11. 6. 2024
  • Supervisor: Mgr. Andrea Knight, Ph.D.
  • Reader: doc. RNDr. Lenka Zdražilová Dubská, Ph.D.

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