Nucleolar Structure and the Role of BYSL Protein in Ribosomopathies – Mgr. Zuzana MACEČKOVÁ
Mgr. Zuzana MACEČKOVÁ
Doctoral thesis
Nucleolar Structure and the Role of BYSL Protein in Ribosomopathies
Nucleolar Structure and the Role of BYSL Protein in Ribosomopathies
Abstract:
V této práci jsme se zaměřili na roli jadérka v buňce. Zkoumali jsme jeho strukturu, indukci nukleárního stresu a jeho účinky. Dále jsme se zabývali DBA, což je vrozená anémie mající původ v aberacích ribozomálních proteinů a jejíž léčba je většinou založena na kortikosteroidech. Prvním aspektem této studie bylo popsání vlivu L-OHP a mutace v RPS7 proteinu na strukturu jadérek. Zjistili jsme, že struktura …moreAbstract:
In this work, we focused on the role of the nucleolus in the cell. We explored its structure, nucleolar stress induction, and its effects. Furthermore, we have explored molecular pathogenesis of Diamond-Blackfan anemia (DBA), which is congenital anemia originating in ribosomal proteins aberration, and it is usually treated by glucocorticosteroids. The first aspect of this study was to estimate the …more
Language used: English
Date on which the thesis was submitted / produced: 7. 9. 2022
Thesis defence
- Supervisor: doc. MUDr. Marián Hajdúch, Ph.D.
Citation record
ISO 690-compliant citation record:
MACEČKOVÁ, Zuzana. \textit{Nucleolar Structure and the Role of BYSL Protein in Ribosomopathies}. Online. Doctoral theses, Dissertations. Olomouc: Palacký University Olomouc, Faculty of Medicine and Dentistry. 2022. Available from: https://theses.cz/id/ok55zs/.
The right form of listing the thesis as a source quoted
MACEČKOVÁ, Zuzana. Nucleolar Structure and the Role of BYSL Protein in Ribosomopathies. Olomouc, 2022. disertační práce (Ph.D.). UNIVERZITA PALACKÉHO V OLOMOUCI. Lékařská fakulta
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Institution archiving the thesis and making it accessible: UNIVERZITA PALACKÉHO V OLOMOUCI, Lékařská fakultaPalacký University Olomouc
Faculty of Medicine and DentistryDoctoral programme / field:
Pediatrics / Pediatrics
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MARKLOVÁ, E.
10/9/2022