Structure-dynamics-function relationships of haloalkane dehalogenases – Mgr. Martin Klvaňa, Ph.D.
Mgr. Martin Klvaňa, Ph.D.
Doctoral thesis
Structure-dynamics-function relationships of haloalkane dehalogenases
Structure-dynamics-function relationships of haloalkane dehalogenases
Abstract:
Pomocí molekulového dokování, molekulově-dynamických simulací, vizualizace struktury a dynamiky proteinu, a ve světle dostupných experimentálních dat byly v halogenalkandehalogenáze DhaA z Rhodococcus rhodochrous NCIMB 13064 navrženy mutace pro zvýšení katalytické účinnosti přeměny jedovaté a nepoddajné xenobiotické sloučeniny, 1,2,3-trichlorpropanu, a vztahy mezi strukturou, dynamikou a funkcí tohoto …moreAbstract:
Using molecular docking calculations, molecular dynamics simulations and visualisation of protein structure and dynamics, and in the light of available experimental data, mutations were designed in haloalkane dehalogenase DhaA from Rhodococcus rhodochrous NCIMB 13064 for enhancing the catalytic performance with toxic and recalcitrant xenobiotic compound, 1,2,3-trichloropropane, and structure-dynamics …more
Language used: English
Date on which the thesis was submitted / produced: 2. 12. 2009
Identifier:
https://is.muni.cz/th/rv1vo/
Thesis defence
- Date of defence: 8. 1. 2010
- Supervisor: doc. RNDr. Miroslav Němec, CSc.
- Reader: prof. RNDr. Luděk Bláha, Ph.D., Assoc. Prof. Jan Florian, dr. Jiří Vondrášek
Citation record
ISO 690-compliant citation record:
KLVAŇA, Martin. \textit{Structure-dynamics-function relationships of haloalkane dehalogenases}. Online. Doctoral theses, Dissertations. Brno: Masaryk University, Faculty of Science. 2009. Available from: https://theses.cz/id/ommlke/.
Full text of thesis
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Published in Theses:- světu
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Institution archiving the thesis and making it accessible: Masarykova univerzita, Přírodovědecká fakultaMasaryk University
Faculty of ScienceDoctoral programme / field:
Biology (4-years) / Microbiology