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Mgr. Roman Sándor, Ph.D.

Doctoral thesis

Metabolism of benzophenanthridine alkaloids and their interaction with G-quadruplexes

Metabolism of benzophenanthridine alkaloids and their interaction with G-quadruplexes
Abstract:
V této práci jsme studovali metabolismus benzofenantridinových alkaloidů (alkaloidy sanguinarin, sanguilutin, sanguirubin, chelerytrin, chelilutin, chelirubin a makarpin) a jejich interakce s nekanonickými strukturami DNA. Enzymatický aparát CYP450 z mikrozomů z potkaních jater byl použit pro produkci metabolitů těchto 7 alkaloidů a ty byly následně detekovány vysokoúčinnou kapalinovou chromatografií …more
Abstract:
In this work, we have studied the metabolism and non-canonical DNA interactions of benzo[c]phenanthridine alkaloids – sanguinarine, sanguilutine, sanguirubine, chelerythrine, chelilutine, chelirubine and macarpine. Rat liver microsomes were used to produce metabolites of the 7 alkaloids by the CYP450 enzymatic apparatus and these were then detected by high-performance liquid chromatography coupled …more
 

Keywords

Benzo[c]phenanthridine alkaloids liquid chromatography mass-spectrometry G-quadruplex cytochrome 450 xenobiotic metabolism
 
Language used: English
Date on which the thesis was submitted / produced: 28. 7. 2022
Identifier: https://is.muni.cz/th/ubgo7/

Thesis defence

  • Date of defence: 8. 11. 2022
  • Supervisor: prof. RNDr. Eva Táborská, CSc.
  • Reader: prof. PharmDr. Karel Šmejkal, Ph.D., doc. RNDr. Jitka Vostálová, Ph.D.

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Institution archiving the thesis and making it accessible: Masarykova univerzita, Lékařská fakulta
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Masaryk University

Faculty of Medicine

Doctoral programme / field:
Physiology, Pathological Physiology, Medical Chemistry and Biochemistry / Medical Chemistry and Biochemistry

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