Mgr. Karin Jaške, Ph.D.

Doctoral thesis

Crossroads of genetics and epigenetics: nucleosome assembly and chromosome integrity

Crossroads of genetics and epigenetics: nucleosome assembly and chromosome integrity
Abstract:
Genetika s epigenetikou se protínají v momentě realizace informace obsažené v genomu. Exprese a opravy DNA jsou determinovány nukleoproteinovou strukturou chromatinu. Sestavování nukleozomů jako základních podjednotek chromatinu je v eukaryotických organismech zajištěno specifickými komplexy proteinů, mezi které patří Chromatin Assembly Factor 1 (CAF1) hrající klíčovou roli v nakládání histonů na vlákno …more
Abstract:
Genetics and epigenetics come across at the moment of the realization of information encoded in the genome. DNA expression and repair are influenced and conditioned by nucleoprotein chromatin structure. Assembly of the nucleosome as the basic unit of chromatin in eukaryotic organisms is guided by special protein complexes and one of them is the Chromatin Assembly Factor 1 (CAF1) playing a crucial role …more
 
 
Language used: English
Date on which the thesis was submitted / produced: 4. 4. 2017

Thesis defence

  • Date of defence: 4. 5. 2017
  • Supervisor: doc. Mgr. Miloslava Fojtová, CSc.
  • Reader: RNDr. Karel Angelis, CSc., RNDr. Roman Hobza, Ph.D.

Citation record

Full text of thesis

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Institution archiving the thesis and making it accessible: Masarykova univerzita, Přírodovědecká fakulta

Masaryk University

Faculty of Science

Doctoral programme / field:
Biochemistry (4-years) / Genomics and Proteomics