Příprava a disoluční kinetika matricových tablet s prodlouženým uvolňováním pentoxifylinu

Alisa D'yachenko

Bachelor's thesis

Preparation and dissolution kinetic study of matrix tablets with extended release of pentoxifylline

Abstract:

The subject of this bachelor thesis is the study of the kinetics of the release of the active pharmaceutical ingredient pentoxifylline from hydrophilic matrix tablets. In the theoretical part is discussed controlled release, dissolution process and suitable pharmacokinetic models. The experimental part focuses on the dissolution of hydrophilic matrix tablets in a dissolving medium of pH 1.2 and subsequent evaluation of obtained dissolution profiles using appropriate mathematical models. The result of this part is to determine the release rate constants of pentoxifylline from various dosage formulations and assessment of the effect of excipients (especially retardant components) on the dissolution profile of the drug.

Abstract:

The subject of this bachelor thesis is the study of the kinetics of the release of the active pharmaceutical ingredient pentoxifylline from hydrophilic matrix tablets. In the theoretical part is discussed controlled release, dissolution process and suitable pharmacokinetic models. The experimental part focuses on the dissolution of hydrophilic matrix tablets in a dissolving medium of pH 1.2 and subsequent evaluation of obtained dissolution profiles using appropriate mathematical models. The result of this part is to determine the release rate constants of pentoxifylline from various dosage formulations and assessment of the effect of excipients (especially retardant components) on the dissolution profile of the drug.

Keywords

hydrophilic matrix tablets, pentoxifylline, dissolution test, controlled drug release

Jazyk práce: English

Datum vytvoření / odevzdání či podání práce: 3. 7. 2018

Zverejniť od: 31. 12. 2999

Obhajoba závěrečné práce

• Vedúci: Ing. Alena Komersová, Ph.D.

University of Pardubice

Faculty of Chemical Technology

Bachelor programme / odbor:
Farmacochemistry and Medicinal Materials / Farmacochemistry and Medicinal Materials