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Mgr. Laura Ondrišová

Bachelor's thesis

Analysis of role of FoxO1 transcription factor in chronic lymphocytic leukemia cells

Analysis of role of FoxO1 transcription factor in chronic lymphocytic leukemia cells
Abstract:
Chronická lymfocytární leukémie (CLL) je nevyléčitelná malignita odvozená od B buněk s komplexní patogenezí, která zahrnuje chromozomální aberace, mutace ve specifických genech, deregulaci BCR signalizace a závislost CLL buněk na jejich mikroprostředí. FoxO1 je transkripční faktor nezbytný pro vývoj a funkci B buněk. Ačkoli byl FoxO1 historicky považován za tumor supresor, vykazuje onkogenní chování …more
Abstract:
Chronic lymphocytic leukemia (CLL) is an incurable B cell derived malignancy with complex pathogenesis that includes chromosomal aberrations, mutations in specific genes, deregulation of BCR signalling, and dependency of CLL cells on their microenvironment. FoxO1 is a transcription factor necessary for development and function of B cells. Although historically considered as a tumour suppressor, FoxO1 …more
 

Keywords

CLL FoxO1 RNA sekvenace B buňky analýza transkripčních faktorů RNA sequencing B cells analysis of transcription factors
 
Language used: English
Date on which the thesis was submitted / produced: 15. 5. 2024
Identifier: https://is.muni.cz/th/wkyw2/

Thesis defence

  • Date of defence: 21. 6. 2024
  • Supervisor: prof. MUDr. Mgr. Marek Mráz, Ph.D.
  • Reader: Mgr. Petr Tauš, Ph.D.

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Institution archiving the thesis and making it accessible: Masarykova univerzita, Přírodovědecká fakulta
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