Modification of Metabolism in Metastatic Tumor Cell Lines as a Potential Therapeutic Strategy – Mgr. Petr Štěpka, Ph.D.
Mgr. Petr Štěpka, Ph.D.
Doctoral thesis
Modification of Metabolism in Metastatic Tumor Cell Lines as a Potential Therapeutic Strategy
Modification of Metabolism in Metastatic Tumor Cell Lines as a Potential Therapeutic Strategy
Abstract:
Změny buněčného metabolismu patří nedílně ke znakům nádorových buněk. Cisplatina představuje běžnou formu chemoterapie, mnoho typů nádorů, včetně pokročilých nádorů prostaty, je ale k jejím účinkům rezistentních. V této práci jsme studovali změny metabolismu aminokyselin, vliv autofagie, mitofagie a účinky reaktivních forem kyslíku s ohledem na působení cisplatinové terapie. Tato doktorská práce se …moreAbstract:
Changes in cell metabolism are an integral part of the hallmarks of cancer cells. Cisplatin is a common form of chemotherapy, but many types of cancer, including advanced prostate cancer, are resistant to its effects. In this study, we investigated the changes in amino acid metabolism, the effect of autophagy, mitophagy and the effects of reactive oxygen species with respect to cisplatin therapy. This …more
Language used: English
Date on which the thesis was submitted / produced: 12. 9. 2023
Identifier:
https://is.muni.cz/th/eh3yk/
Thesis defence
- Date of defence: 15. 12. 2023
- Supervisor: prof. PharmDr. Petr Babula, Ph.D.
- Reader: doc. Ing. Milan Jakubek, Ph.D., doc. MUDr. Adela Penesová, PhD.
Citation record
ISO 690-compliant citation record:
ŠTĚPKA, Petr. \textit{Modification of Metabolism in Metastatic Tumor Cell Lines as a Potential Therapeutic Strategy}. Online. Doctoral theses, Dissertations. Brno: Masaryk University, Faculty of Medicine. 2023. Available from: https://theses.cz/id/srch8z/.
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Institution archiving the thesis and making it accessible: Masarykova univerzita, Lékařská fakultaMasaryk University
Faculty of MedicineDoctoral programme / field:
Physiology, Pathological Physiology, Medical Chemistry and Biochemistry / Physiology
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