Mgr. Lenka Umannová, Ph.D.

Doctoral thesis

Mechanisms of action of toxic aromatic compounds in vitro.

Mechanisms of action of toxic aromatic compounds in vitro.
Abstract:
V této práci jsou shrnuty výsledky zabývající se vlivem modelového prozánětlivého cytokinu na různé toxické efekty, způsobené aktivací AhR, v jaterní progenitorové buněčné linii WB-F344 odvozené z jater potkana, kdy jsme se zaměřili zvláště na deregulaci buněčné proliferace v kontaktně-inhibovaných buňkách, expresi cytochromů P450 1 (CYP1) enzymů a indukci poškození DNA mutagenními ligandy AhR.
Abstract:
The present thesis summarizes the results of our studies exploring the impact of model pro-inflammatory mediator on various toxic effects mediated by AhR activation in a model of rat liver progenitor cells WB-F344, which concentrated especially on deregulation of cell proliferation in contact-inhibited cells and expression of cytochrome P450 1 (CYP1) enzymes or induction of DNA damage and genotoxicity …more
 

Keywords

AhR cytochromes P450 inflammation polychlorinated dibenzo-p-dioxins polychlorinated biphenyls polycyclic aromatic hydrocarbons contact inhibition proliferation DNA-adducts
 
Language used: English
Date on which the thesis was submitted / produced: 7. 8. 2009
Identifier: https://is.muni.cz/th/pfn4y/

Thesis defence

  • Date of defence: 21. 9. 2009
  • Supervisor: prof. RNDr. Jan Vondráček, Ph.D.
  • Reader: doc. RNDr. Zdeněk Dvořák, Ph.D., RNDr. Ludovít Mušák, Ph.D.

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Institution archiving the thesis and making it accessible: Masarykova univerzita, Přírodovědecká fakulta
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Masaryk University

Faculty of Science

Doctoral programme / field:
Biology (4-years) / Animal Physiology

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