Telomere length compensation mechanisms as players in longevity and stress adaptation of insects

RNDr. Michala SÁBOVÁ

Disertační práce

Anotace:

Telomeres are nucleoprotein structures at the ends of eukaryotic chromosomes that are important for genome stability and integrity. They are shortened with each cell cycle and during organismal aging. Although the most common telomere length compensation mechanism is the activity of a special reverse transcriptase, telomerase, in Drosophila telomeres are maintained by the retrotransposition of telomeric elements. In mammals, telomere length and telomerase activity can be influenced by lifestyle and the environmental conditions. This thesis is focused on activity of telomere length maintenance mechanism in insects in relation to aging and stress response.

Abstract:

Telomeres are nucleoprotein structures at the ends of eukaryotic chromosomes that are important for genome stability and integrity. They are shortened with each cell cycle and during organismal aging. Although the most common telomere length compensation mechanism is the activity of a special reverse transcriptase, telomerase, in Drosophila telomeres are maintained by the retrotransposition of telomeric elements. In mammals, telomere length and telomerase activity can be influenced by lifestyle and the environmental conditions. This thesis is focused on activity of telomere length maintenance mechanism in insects in relation to aging and stress response.

Klíčová slova

Telomeres, telomerase, honey bee, Apis mellifera, Drosophila melanogaster, oxidative stress, aging, longevity, cost of reproduction

Jazyk práce: čeština

Datum vytvoření / odevzdání či podání práce: 10. 10. 2017

Obhajoba závěrečné práce

• Obhajoba proběhla 29. 11. 2017
• Vedoucí: Mgr. Radmila Čapková Frydrychová, Ph.D.

JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH

Přírodovědecká fakulta

Doktorský studijní program / obor:
Fyziologie a imunologie / Fyziologie a vývojová biologie