Farmakologicky a biochemicky významné kumariny

Mirjeta Kafexholli

Bachelor's thesis

Pharmacologically and biochemically important coumarins

Abstract:

Bolo pripravených päť enaminonov na báze 7-aminokumarínov. Ich štruktúra bola volená tak aby vykazovali zaujímavé optické vlastnosti napr. trifenylamínový a tetrafenylethylénový fragment. Následne bolo z príslušných enaminonov reakciou s trojmocným bórom pripravené oxazaboríny. Predstavujú kombináciu dvoch luminoforov: 7-aminokumarínu a boron ketiminátu. Pripravené zlúčeniny boli charakterizované pomocou multinukleárnej magnetickej rezonancie a boli vykonané predbežné štúdia ich fluorescenčných vlastností.

Abstract:

Five 7-aminocoumarin-based enaminones were prepared. Their structure has been chosen to exhibit the interesing optical properties, such as triphenylamine and tetraphenylethylene fragment. The prepared enaminones were subjected to the reaction with the compounds of trivalent boron to give the corresponding oxazaborines having both BF2 and BPh2 fragment.These compounds are the combination of two luminophores: 7-aminocoumarin and boron ketiminate. The oxazaborines were characterized by means of multinuclear magnetic resonance and the preliminary survey of their luminescence properties has been performed.

Keywords

Kumarínové derívaty, enaminony, fluorescencia, oxazaboríny

Language used: Czech

Date on which the thesis was submitted / produced: 3. 7. 2018

Accessible from:: 31. 12. 2999

Thesis defence

• Supervisor: doc. Ing. Petr Šimůnek, Ph.D.

University of Pardubice

Faculty of Chemical Technology

Bachelor programme / field:
Farmacochemistry and Medicinal Materials / Farmacochemistry and Medicinal Materials