Vliv vrozených hyperkoagulačních stavů na hladinu D-d se zaměřením na gravidní ženy

Bc. Zuzana ŠTÍCHOVÁ

Diplomová práce

Abstract:

The thesis analyses the female patients' data from Clinical hematology department in České Budějovice hospital from year 2014 to 2015 and tries to statistically confirm connection between D-dimer level and hypercoagulable states described in previous bachelor thesis. D-dimer assay is due to negative predictive value and high sensitivity an initial laboratory test to rule out tromboembolic disease. However, it has low specificity. The elevated level of D-dimer is observed in conditions like infection, trauma, acute cancer, recent surgery or pregnancy and last studies showed increased D-dimer level even in combination with inherited hypercoagulable states. Thus, it is necessary to analyse the level of D-dimer in pregnant women related to specific hypercoagulable states. Moreover, the thesis analyses the influence of other factors like anticoagulation therapy on D-dimer level and tries to find connection between D-dimer level and pregnancy associated complication, birth weight or a type of delivery.

Klíčová slova

hyperkoagulační stav, trombofilie, D-dimery, Leidenská mutace, tromboembolická nemoc, gravidita

Jazyk práce: čeština

Datum vytvoření / odevzdání či podání práce: 13. 12. 2017

Obhajoba závěrečné práce

• Vedoucí: MUDr. Ivan Vonke

JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH

Přírodovědecká fakulta

Magisterský studijní program / obor:
Biologie / Klinická biologie