Mgr. Jana Laláková, Ph.D.

Doctoral thesis

A role of the TRAMP complex in RNA processing and turnover

A role of the TRAMP complex in RNA processing and turnover
Abstract:
V této práci jsme zkoumali funkce a mechanismy, pomocí kterých je TRAMP zapojen do transkripce, zpracování a kontroly kvality RNA v Saccharomyces cerevisiae. Úspěšně jsme odhalili, jak se jednotlivé podjednotky skládají do komplexu, jak TRAMP rozezná a váže molekuly RNA a nastínili jsme roli domény KOW v proteinu Mtr4p při aktivaci exozomu. Také jsme charakterizovali specificitu substrátů rozeznávaných …more
Abstract:
In this thesis, we have investigated the function and mechanisms by which is TRAMP involved in RNA transcription, processing and quality control in Saccharomyces cerevisiae. Briefly, we successfully uncovered a puzzle of the RNA binding and assembly of the TRAMP complex and suggest a role of the KOW domain of Mtr4p in the exosome activation. We have also characterized the substrate specificity of Air2p …more
 

Keywords

komplex TRAMP procesování a degradace RNA RNA polymeráza II terminace transkripce exozom model torpédo TRAMP complex RNA processing and degradation RNA polymerase II transcription termination exosome torpedo model
 
Language used: English
Date on which the thesis was submitted / produced: 28. 11. 2014
Identifier: https://is.muni.cz/th/nlyf1/

Thesis defence

  • Date of defence: 10. 12. 2014
  • Supervisor: doc. Mgr. Štěpánka Vaňáčová, Ph.D.
  • Reader: RNDr. Martin Pospíšek, PhD., Mgr. Libor Krásný, PhD.

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