Bc. Barbora Štefanovie

Master's thesis

Charakterizace DSS1 proteinových interakcí

Characterization of the DSS1 protein interaction
Abstract:
Malý kyslý ľudský proteín DSS1 interaguje s tumor supresorovým proteínom BRCA2, ktorý pôsobí ako rekombinačný mediátor pri procese opravy DNA pomocou homologickej rekombinácie. Napriek tomu, že štruktúra DSS1 proteínu je známa, a že DSS1 interaguje s proteínom BRCA2, jeho funkcia v procese homologickej rekombinácie zostáva neobjasnená. Táto diplomová práca popisuje funkčnú spojitosť medzi proteínom …more
Abstract:
DSS1 is a small acidic protein, which interacts with BRCA2, a tumor suppressor protein, that acts as a recombination mediator during DNA repair mediated by the process of homologous recombination. Despite its known structure and interaction with BRCA2 protein, the function of DSS1 protein during the homologous recombination remains unclear. Here, we describe functional connection between DSS1 and hRPA …more
 

Keywords

homologous recombination DSS1 protein DNA repair RPA protein hRAD52 protein
 
Language used: English
Date on which the thesis was submitted / produced: 12. 5. 2011
Identifier: https://is.muni.cz/th/j2pxu/

Thesis defence

  • Date of defence: 7. 6. 2011
  • Supervisor: doc. Mgr. Lumír Krejčí, Ph.D.

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