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Mgr. Mária Hricková

Advanced ('rigorózní') thesis

Efekt CNQX v modeli závislosti na nikotíne a metamfetamíne

Effect of CNQX in the model of nicotine and methamphetamine dependecence
Abstract:
Addiction is a disease with limited treatment options. The study aimed to evaluate the effect of CNQX, an AMPA/kainate receptor antagonist, on nicotine and methamphetamine self-administration in rats. We administered CNQX (3-6 mg/kg) and observed its effect on drug intake and drug-seeking. CNQX reduced nicotine intake but did not affect intake or seeking of methamphetamine. Since CNQX also has an affinity …more
Abstract:
Závislosť je ochorenie, ktorého liečba je obmedzená. Cieľom štúdie bolo zhodnotiť účinok CNQX, antagonistu AMPA/kainátových receptorov, na príjem a vyhľadávanie nikotínu a metamfetamínu v animálnom modeli. Potkanom sme podali CNQX (3-6 mg/kg), a sledovali príjem a vyhľadávanie drog. CNQX znížilo príjem nikotínu, ale neovplyvnilo príjem ani vyhľadávanie metamfetamínu. Účinok CNQX vysvetľujeme rozdielnym …more
 

Keywords

AMPA/kainátový receptor CNQX Nikotín Metamfetamín Operantná autoaplikácia AMPA/kainate receptor Nicotine Methamphetamine Self-administration
 
Language used: Slovak
Date on which the thesis was submitted / produced: 31. 7. 2023
Identifier: https://is.muni.cz/th/b55je/

Thesis defence

  • Date of defence: 8. 11. 2023
  • Supervisor: PharmDr. Bc. Kateřina Horská, Ph.D.
  • Reader: doc. MVDr. Pavel Suchý, Ph.D., doc. PharmDr. Magdaléna Šustková, CSc.

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Institution archiving the thesis and making it accessible: Masarykova univerzita, Farmaceutická fakulta
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Masaryk University

Faculty of Pharmacy

Advanced ('rigorózní řízení') programme / field:
Pharmacy / Pharmacy

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