Regulation of structure-specific endonucleases – Mgr. Alexandra Sisáková, Ph.D.
Mgr. Alexandra Sisáková, Ph.D.
Doctoral thesis
Regulation of structure-specific endonucleases
Regulation of structure-specific endonucleases
Abstract:
Homológna rekombinácia je opravný mechanizmus podieľajúci sa na udržovaní stability genómu opravou dvojreťazcových zlomov na DNA. Táto cesta zahŕňa množstvo rôznych faktorov, vrátane štruktúrne-špecifických nukleáz, ktoré sú nevyhnutné pre štiepenie medziproduktov DNA vznikajúcich počas opravy a DNA replikácie. Nukleázy, ako aj ďalšie enzýmy musia byť presne regulované, čo je umožnené v mnohých prípadoch …moreAbstract:
Homologous recombination is a repair mechanism involved in the genome integrity maintenance by repairing DNA double strand breaks. This pathway involves a number of different factors, including structure-specific nucleases, which are essential for processing of DNA intermediates arising during the repair and DNA replication. Nucleases, as well as other enzymes must be strictly regulated, which is achieved …more
Language used: English
Date on which the thesis was submitted / produced: 5. 6. 2017
Identifier:
https://is.muni.cz/th/h8s1x/
Thesis defence
- Date of defence: 21. 9. 2017
- Supervisor: doc. Mgr. Lumír Krejčí, Ph.D.
Citation record
Full text of thesis
Contents of on-line thesis archive
Published in Theses:- světu
Other ways of accessing the text
Institution archiving the thesis and making it accessible: Masarykova univerzita, Lékařská fakultaMasaryk University
Faculty of MedicineDoctoral programme / field:
Medical Biology (4-years) / Medical Biology
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